Centre for Bone and Arthritis Research

 
Welcome to our research centre. We rely on a multidisciplinary translational approach with the overall aim to improve the prevention, diagnosis and treatment of osteoporosis and rheumatoid arthritis, two of the most common diseases in Sweden.

 
News 
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Publications:

Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis.
Clin Exp Immunol. 2011 Jul;

Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis.
Clin Immunol. 2011 Jul

Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis.
Arthritis Res Ther. 2011 Jun 

Hormone replacement therapy in postmenopausal women with rheumatoid arthritis stabilises bone mineral density by digital x-ray radiogrammetry in a randomised controlled trial.
Ann Rheum Dis. 2011 Jun

Östrogenbehandling utan biverkningar i sikte
http://medicinskaccess.se/index.php/Nyheter/Ostrogenbehandling-utan-biverkningar-i-sikte.html

Roles of transactivating functions 1 and 2 of estrogen
receptor-{alpha} in bone
Proc Natl Acad Sci USA. 2011 Apr

Estrogens in rheumatoid arthritis; the immune system and bone.
Mol Cell Endocrinol. 2011 Mar

Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis.
BMC Musculoskelet Disord. 2010 Dec

The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth.
J Bone Miner Res. 2010 Dec

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nat Genet. 2010 Nov

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.
PLoS Genet. 2010 Nov  

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nat Genet. 2010 Nov

Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature. 2010 Oct

Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different pathways.
J Mol Endocrinol. 2010 Jul